Selasa, 31 Juli 2012

GOLD MEDAL DREAMING*


LET the Games begin! As the 2012 Olympic Games get underway in London, the spirit of competition and international goodwill that characterises the Olympics offers a rare chance to enjoy and admire excellence in abundance.

It is no surprise that another highly competitive field — health and medical research — holds an event modelled on the Olympic Games. In 2009, Beijing reprised its hosting of the 2008 Olympic Games, with a medical and surgical Olympiad, sponsored by the International Association of Surgeons, Gastroenterologists and Oncologists in collaboration with the Chinese Society of Surgery and the Chinese Medical Association.

Attending doctors competed, using scientific papers as their currency, the best receiving gold medals.

The Greek Embassy in Beijing described how the closing ceremony of the medical Olympics was dedicated to “the Greek culture, its scientific and medical history, and of course, to the renowned Greek physician Hippocrates who was born in the island of Kos in the Aegean in 460 BC and has been considered one of the most outstanding figures in the history of medicine”.

Greece hosted the first international medical Olympiad in 1996 on the island of Kos.

A different style of health-related Olympics was created by American filmmaker Michael Moore, known for his work on a number of satirical documentaries, including Sicko, an exposé of the inequalities and inefficiencies of the American health care system. Before Sicko, Moore created TV Nation: The Health Care Olympics, where Canada, the US and Cuba were matched against each other in three competitive races, involving the care of legs, ankles and feet, respectively.

This Olympic backdrop does raise the question of how much competition is good for health care.

Private enterprise enthusiasts suggest that we need a lot more competition than we currently have to “drive” efficiency. “Drive” is the new best friend of young managers so caution is advised with any rhetoric that uses it.

Competition may push health care towards excellence — and who could dispute that parts of the US health care system are the best in the world for those who can pay. The problem is the huge disparities that occur in quality of care for those who cannot pay.

What we need is a new set of medals for achieving equity, humanity and reasonable efficiency.

In that race Australia would do well, while at the same time winning many prizes for excellence of care much to the amazement of the market fundamentalists.

The irony is, of course, that while “One World One Dream” was the catchphrase for the Beijing Olympics, there is ultimately no way in our unequal world that a universal dream — the fulfilment of the human right to access to basic health care — can persist into wakefulness … not with more than 3 billion people living on less than $2.50 a day.

We must go beyond the Olympics to find the ethical inspiration needed to enable us to address poverty and inequality to achieve that dream.

Gold, indeed.

*Previously published in MJA InSight

Selasa, 24 Juli 2012

How Should Science be Done?

Lately I keep running into the idea that the proper way to do science is to continually strive to disprove a hypothesis, rather than support it*.  According to these writers, this is what scientists are supposed to aspire to, but I've never actually heard a scientist say this.  The latest example was recently published in the Wall Street Journal (1).  This evokes an image of the Super Scientist, one who is so skeptical that he never believes his own ideas and is constantly trying to tear them down.  I'm no philosopher of science, but this idea never sat well with me, and it's contrary to how science is practiced. 
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Minggu, 22 Juli 2012

New Review Paper by Yours Truly: High-Fat Dairy, Obesity, Metabolic Health and Cardiovascular Disease

My colleagues Drs. Mario Kratz, Ton Baars, and I just published a paper in the European Journal of Nutrition titled "The Relationship Between High-Fat Dairy Consumption and Obesity, Cardiovascular, and Metabolic Disease".  Mario is a nutrition researcher at the Fred Hutchinson Cancer Research Center here in Seattle, and friend of mine.  He's doing some very interesting research on nutrition and health (with an interest in ancestral diets), and I'm confident that we'll be getting some major insights from his research group in the near future.  Mario specializes in tightly controlled human feeding trials.  Ton is an agricultural scientist at the University of Kassel in Germany, who specializes in the effect of animal husbandry practices (e.g., grass vs. grain feeding) on the nutritional composition of dairy.  None of us have any connection to the dairy industry or any other conflicts of interest.

The paper is organized into three sections:
  1. A comprehensive review of the observational studies that have examined the relationship between high-fat dairy and/or dairy fat consumption and obesity, metabolic health, diabetes, and cardiovascular disease.
  2. A discussion of the possible mechanisms that could underlie the observational findings.
  3. Differences between pasture-fed and conventional dairy, and the potential health implications of these differences.

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Kamis, 19 Juli 2012

What Causes Type 2 Diabetes, and How Can it be Prevented?

In the comments of the last post, we've been discussing the relationship between body fatness and diabetes risk.  I think this is really worth understanding, because type 2 diabetes is one of the few lifestyle disorders where 1) the basic causes are fairly well understood, and 2) we have effective diet/lifestyle prevention strategies that have been clearly supported by multiple controlled trials.

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Kamis, 12 Juli 2012

Interview with Aitor Calero of Directo al Paladar

Aitor Calero writes for the popular Spanish cooking and nutrition blog, Directo al Paladar ("straight to the palate").  We did a written interview a while back, and he agreed to let me post the English version on my blog.  The Spanish version is here and here.

Without further ado, here it is:

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Selasa, 10 Juli 2012

THE MEDICARE LOCAL AS ORCHESTRA!*


I want to try out an idea with you. 

Everyone I meet is struggling to say what a Medicare Local is and what it should do.  I would like to propose an analogy – that Medicare Locals are like large chamber orchestras – many instruments and an unobtrusive conductor who may be one of the principal players with special leadership skills.  

Many Divisions of General Practice operated well, bringing general practitioners together for fellowship, education and program development and into better working relations with community health and allied health professionals.  But with the advent of Local Hospital (or Health) Networks (or Districts), whose size makes good sense in terms of the skill mix that can be maintained to meet the health needs of the community and managerial effectiveness, we need an organisation in the community that more or less matches the networks in size.  One day, I prophesy, Medicare Locals and Hospital Networks will work together seamlessly and be funded from one source.  Not for now.

The music that Medicare Locals make occurs when the various players are in tune (no matter their instrument) and in time and they stick to a score.  You need many different players and instruments – one of this and half a dozen of that – to get the best results depending on the music.  Rehearsal is critical as is discipline and enjoyment from working well together.

OK – let’s run with the chamber orchestra idea for a bit. What music does it play? 

First let me tell you about a cold winter’s evening a couple of weeks ago when I had the privilege of meeting with about 50 local people in the Carrington Hotel in Katoomba (NOT what you’re thinking!) to talk with them and colleagues from the Nepean-Blue Mountains Medicare Local (ML) about the health needs of their community and how the ML might help to meet those needs.

Once we got over the hurdle of ‘what on earth is a ML?’ the conversation was wonderfully open, focussed, concerned.  I was especially impressed with how often people were thinking well beyond themselves and their own needs, and instead considering the community itself.  Several needs popped up from all over the room – linkage among care providers for patients with continuing and complex problems, mental health and transport. Let’s locate them in the Medicare Local.

Symphony in C Major?  It depends on better linkage among the care providers for people who access different health services.  Time and time again we heard about failed hook-up among providers of care for chronically ill older people.  Yes, yes, I know – when the day of the personal electronic record has fully come all many communication problems will be solved.  In the meantime, we should be thinking about a patient-controlled note book (pen and paper variety) into which the patient puts details of each consultation. 

Many general practitioners have formed informal email and telephone linkages with specialists and other carers and coordinate through those media.  Hospitals increasingly fax or email summaries to general practitioners after patients have been discharged, but more is needed. 

With the pen-and-paper book (and yes, a few will get lost or forgotten) health care professionals may be able to help with summaries that could be printed and stuck into the book, including meds and doses.  By whatever means, we need a common score to play from.

That way when, as one general practitioner put it, a patient with a complex chronic problem consults them, they will be able to go beyond just asking the patient what has been happening to them with other health care providers.

And vice versa – when patients turn up at hospitals at 2 am it would often be helpful to have more detailed accounts of what has been happening.

But you can imagine how much better this symphony would sound if everyone had the same musical score to play from. The RACGP Blue Book gives us a happy precedent: we need something similar for grown-ups.  The ML could help by first sussing out what communication networks exist and work well and where much more work is needed.

Concerto in D Minor?  That must surely be mental health. The Katoomba people perceived many different aspects of this broad-spectrum problem.  Disturbances of mental health come in all shapes, sizes and degrees of severity. We agreed that a blend of community and institutional care is needed and that opportunities for prevention, especially among young people, are frequently slipping through our fingers. How could the ML help?

A comprehensive ML should be in close touch with psychologists, general practitioners, community health, psychiatrists and the education authorities.  This is not impossible and if given real priority could work brilliantly.  All that was said about the need for far better communication among the players in chronic disease symphony can be said for mental health as well. There are so many commissions, reports, inquiries, and task forces that circle the planet like satellites at present that it is hard to know how to use them to best effect.  In the meantime we should focus on the local scene.

Then the third symphony where we need a strong conductor and players recruited from beyond the health arena is transport.  People at the Katoomba meeting meant transport of all forms.  Patients coming from Lithgow – hardly a distant country town – can catch a train to Sydney or Katoomba only once every two hours.  This may be fine if you’re fit but it can impose huge burdens on those who are unwell.  An appointment in Penrith, Westmead or Sydney runs late and you miss a train by five minutes – wait 1 hour and 55 minutes for the next one, with your arthritis, heart failure or COPD.  Tough luck.

Buses often follow routes that do not suit the chronically ill.  Years ago I worked with a bus company in western Sydney that changed its routes after consultation to better serve the needs of older citizens, so change is possible.  By default the ambulance service is pressed into service. 

An ML might seek to learn in detail what transport needs for health care its community has and then advocate with local government and state government departments to organise services better.  That’s a reasonable aim in a democracy.  We bang on about keeping patients with chronic illness out of hospital.  Well, by improving transport for them we may help achieve this goal.

The Medicare Local is not just another institution.  It is a way of organising community-minded health professionals and others interested in the health of the citizenry so that good music follows.  Because of its complexity and function it is a hard idea to get.  Medicare Locals need people to take music seriously – tune up, coordinate, cooperate, read the score (don’t guess), practice and enjoy.  After all the word orchestra literally means ‘a dancing place’ so feel free! 


*Previously published in AusDoc

Minggu, 01 Juli 2012

Why Did Energy Expenditure Differ Between Diets in the Recent Study by Dr. Ludwig's Group?

As discussed in the previous post, a recent study by Dr. David Ludwig's group suggested that during weight maintenance following fat loss, eating a very low carbohydrate (VLC) diet led to a higher metabolic rate (energy expenditure) than eating a low-fat (LF) diet, with a low glycemic index (LGI) diet falling in between the two (1).  The VLC diet was 30 percent protein, while the other two were 20 percent.  It's important to note that these were three dietary patterns that differed in many ways, and contrary to claims that are being made in the popular media, the study was not designed to isolate the specific influence of protein, carbohydrate or fat on energy expenditure in this context. 

Not only did the VLC diet lead to a higher total energy expenditure than the LF and LGI diets, the most remarkable finding is that it led to a higher resting energy expenditure.  Basically, people on the VLC diet woke up in the morning burning more energy than people on the LGI diet, and people on the LGI diet woke up burning more than people on the LF diet.  The VLC dieters burned 326 more calories than the LF dieters, and 200 more than the LGI dieters.

It's always tempting to view each new study in isolation, without considering the numerous studies that came before it, but in this case it's essential to see this study through a skeptical lens that places it into the proper scientific context.  Previous studies have suggested that:
  1. The carbohydrate:fat ratio of the diet has little or no detectable impact on energy expenditure in people who are not trying to lose weight (2, 3).
  2. The carbohydrate:fat ratio of the diet has little or no detectable impact on energy expenditure in people who are being experimentally overfed, and if anything carbohydrate increases energy expenditure more than fat (4, 5).
  3. The carbohydrate:fat ratio of the diet has little or no detectable impact on energy expenditure during weight loss (6, 7, 8), and does not influence the rate of fat loss when calories are precisely controlled. 
This new study does not erase or invalidate any of these previous findings.  It fills a knowledge gap about the effect of diet composition on energy expenditure specifically in people who have lost weight and are trying to maintain the reduced weight.

With that, let's see what could have accounted for the differences observed in Dr. Ludwig's study.
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